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NAD+ is a crucial coenzyme in our bodies. It is central to anti-aging through energy metabolism and cell function. Research shows that aging is accompanied by a gradual decline in cellular NAD+ levels. Maintaining NAD+ levels is essential to general health, graceful aging, and cognitive function.

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Nicotinamide (NAM)

NAD+ consists of two nucleotides joined together, and one of these nucleotides is nicotinamide. Nicotinamide is derived from niacin (vitamin B3) through enzymatic processes.



The other nucleotide in NAD+ is adenine, a nitrogenous base. Adenine is also a component of adenosine diphosphate (ADP) and adenosine triphosphate (ATP), which are involved in cell energy transfer.



A ribose sugar molecule links the nucleotides in NAD+. Ribose is a pentose sugar, meaning it has five carbon atoms.

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme involved in key biological processes:

  1. Energy Metabolism: NAD+ facilitates energy transfer in cellular respiration, converting nutrients into ATP.

  2. Oxidative Stress Defense: It helps cells combat oxidative damage, maintaining redox balance.

  3. DNA Repair: NAD+ aids in repairing damaged DNA through PARP enzymes.

  4. Sirtuin Activation: NAD+ activates sirtuins, which regulate gene expression, DNA repair, and longevity.

  5. Cellular Regulation: NAD+ is involved in signaling pathways, calcium signaling, and circadian rhythms.

  6. Mitochondrial Function: It supports ATP production in mitochondria.

  7. Cellular Longevity: NAD+ is linked to cellular aging processes.

  8. Metabolic Diseases: Dysregulation of NAD+ metabolism is implicated in metabolic disorders.


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